Genetic testing for colorectal cancer

If you have a history of colorectal cancer in your family, we recommend a genetic test to see if you are at risk for the disease.

Statistically, colorectal cancer affects one in 20 people. About 25% have a family history of recurrent cases of the disease. However, in addition to hereditary predisposition, the influence of many other factors besides genetics cannot be discounted. And only 5% of all cases can be considered directly hereditary.

Lynch syndrome is considered a hereditary nonpolyposis colon cancer. And it accounts for the majority of genetically determined colorectal cancer cases (2-3% of all cases).

Who is recommended to have a genetic test for colorectal cancer?

A person whose family history suggests a predisposition to the development of genetically determined colorectal cancer. These factors include :

A family history of early onset :

  • Colorectal or endometrial cancer before the age of 50
  • Colorectal cancer before the age of 60 and high frequency microsatellite instability on histological analysis

Multiple polyps in the colon :

  • Colorectal adenomatous polyps (if more than 10)
  • Gamartoma gastrointestinal polyposis

Family history :

  • Patient whose close family members include several people with colorectal cancer or Lynch Syndrome.

Benefits of genetic tests to reduce risk:

Determining the right strategy to control or even manage the disease is possible. First, we need to obtain reliable clinical data, namely to determine the presence of a pathogenic mutation to link the clinical phenotype to a specific type of genetically determined colorectal cancer or associated syndrome.


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