Cancer: understanding why aggressive cells develop in healthy tissues
 
Geneva:
+4122 840 33 34
 
Moscow:
+7(903)720 80 57

Another step towards understanding cancer

Date: 21/08/2015
Last edited: 21/08/2015

A team based in Bern emphasize the importance of aggressive cells’ development in healthy tissues, opening the way for potential new treatments.

Researchers supported by the Swiss National Science Foundation have discovered how aggressive cells can invade healthy tissue in the early stages of tumor development. This breakthrough opens a new way to attack cancer at its beginning.

When healthy cells of the body are beyond the control of their peers, they can cause tumor formation and eventually lead to cancer. Scientists are trying to understand exactly how the cells manage to emancipate themselves from this surveillance.

The team of Eduardo Moreno, professor at the Institute of Cell Biology of the University of Bern, has discovered that a mechanism normally implemented during the early formation of the embryo could participate in the early phases of the development of tumors in adults.

The role of Myc gene

As part of their project, the researchers filmed under the microscope during several hours developing cells of pupae Drosophila. These genetically altered fruit flies carried a gene called Myc known for his oncogene role and it had been artificially activated.

By itself, this gene proved sufficient to induce abnormal cells to proliferate, to intrude among the healthy cells and eliminate them to take their place. The observed process is a mechanism of invasion of unexpected tissue that occurs in the first stage of development of tumor diseases.

A model applicable to most cancers

“The activation of this gene gave to the cells special mechanical properties that helped them to mingle with healthy cells, to circle them, and finally to more effectively eliminate them” says Romain Levayer, first author of the study.

“If it was known that this invasion mechanism is activated during embryonic development, when cells are reorganizing to change body shape, we have shown that they are able to use the same program to invade healthy tissue,”says group leader Eduardo Moreno.

The famous military strategy “Divide and conquer” is the formula used by researchers to describe the behavior of these aggressive cells.

Develop new strategies

The mechanism highlighted, which differs from the invasion of metastatic mechanisms observed in the later stages of tumor development, could explain how tumors associated with most types of cancer appear.

“We studied this phenomenon on pupae of fruit flies, we had chosen to model because their genes can be easily modified. Since pupae do not move and they are transparent, it is also easy to observe under the microscope “continues Eduardo Moreno.

Nearly 90 percent of cancers are formed in epithelial tissues similar to those filmed in pupae: colon, skin and mammary glands. The deregulated Myc gene is that which is most often found in tumors. This newly identified mechanism could therefore apply to the majority of cancers and help scientists to develop new strategies to prevent tumors from their training, before the tissues have substantially damaged.

(ats/Newsnet)

Comments
Articles
Patient registration form
Topics
Examination Incorpore
nutrition
oncology
prevention
cancer
dermatology
age management
Anti-aging
detoxification
skin
heavy metal
diagnosis
immunology
allergy
cardiology
DNA
weight management
stem cells
Fertility
liver detox
Genetics
pain
oncology treatment
cosmetology
weight loss
liver
gastroenterology
covid19
urology
Examination partner centres
chelation
Sleep
gynecology
heart MRI
infertility
obstetrics
pregnancy
anti-aging
radiology
headache
check-up
arsenic
Hepatitis C
candida
rehabilitation
neurology
immune system
immunotherapy
probiotics
NAD+
Apnea
mesotherapy
joints
tinnitus
Blood pressure
breast cancer
Дерматология
skincare
migraine
beau-rivage
gastritis
Allergology
Allergology treatment
pancreas
sugar
research
menopause
abdominal pain
ulcer
hyaluronic acid
sexuality
nutrigenomics
flu vaccine
andropause
light therapy
excimer laser
psoriasis
telomere
regeneration
PRP
obstertics
rhesus factor
preventiion
gastroscopy
brain surgery awake
mastectomy
digestion
mammography
cellmen
cellcosmet
herniated disc
flu
magnesium
R-loops
Omega-3
shoulder
hand
intestinal flora
depression
iron
second opinion
food intolerances
reflexology
food
vitamin b12
mercury
water
erectile dysfunction
back pain
hip
knee
beauty
exercise
sports
cholesterol
stress
vitamin K
narcosis
diabetes
cellulite
acnea
migraines
chronic headaches
diet
oncoloy
reconstruction
blood test
endometriosis
acne
LED therapy
biopsy
liquid biopsy
oral checkup
propofole
dermatitis
hormones
general surgery
nephrology
kidney
ophthalmology
plastic surgery
lungs
pneumology
proctology
pomegranate
rheumatology
orthopedics
colonoscopy
endocrinology
Treatment programs